No, if you care about its value. Sharpening removes steel permanently, changes the factory edge geometry, and marks the knife as a user rather than an unused piece. The factory edge is part of what a collector is buying, and it cannot be put back.
The original factory edge is evidence that the knife was never used. Once it is gone, no amount of skilled sharpening restores it, and the knife moves permanently into the user category.
On traditional slip joints there is a second cost: repeated sharpening eventually takes the blade past the kick, which is genuinely the end of a knife's life.
If the knife is already a user, sharpen it and enjoy it. If it has already been sharpened by a previous owner, the collectible condition is gone and there is nothing left to protect.
And if you simply want to use it more than you want to hold value, that is a legitimate choice. Just make it deliberately.
Skin oils promote corrosion, so handle stored pieces with clean dry hands or cotton gloves, and wipe them afterwards. Keep the box.
See storing a collection and what adds value.