Start the choice with how each is made: UltreX describes G-10 as fiberglass and epoxy resin formed under high temperature and pressure, and CIVIVI calls FRN "a type of thermoplastic material that is reinforced with glass fibers." Kershaw says glass threads give nylon "increased strength, stiffness, and dimensional stability," while UltreX says G-10 "will not melt."
By their makers' accounts, G10 and glass-filled nylon reach a knife by different routes. On the G10 side, Norplex-Micarta says its thermoset sheet arrives fully cured and ready for stock removal such as milling and water jet cutting, and UltreX says G-10 laminate, built from fiberglass and epoxy resin, is "unlike other polymers" in that "it will not melt."
On the nylon side, CIVIVI calls fiber-glass reinforced nylon a thermoplastic reinforced with glass fibers, and Böker says the materials named Zytel are based on thermoplastic polyamides, "nylon-like plastics that can be shaped at high temperatures." Gerber's blog calls the Gator's design "an injection molded frame with a rubber overmold handle"; for any other model, how the handle is shaped is its maker's to say.
Kershaw, CIVIVI and Gerber each name a different gain. Kershaw says nylon is reinforced with glass threads "for increased strength, stiffness, and dimensional stability, combined with excellent wear resistance." CIVIVI calls its FRN "resistant to impact, abrasion, and moisture," and Gerber says the glass-filled nylon handle on its LST Ultra "is light and grippy."
None of these lines sets glass-filled nylon against G10, so a buyer chooses by the description that fits the job. Cleaning a glass-filled nylon handle has its own answer in caring for an FRN handle.
Product data names glass-filled nylon several ways, so the word in the Handle row changes from listing to listing. Each word sits with what its maker or owner says; none shows a shared formulation.
In a listing's name, GRN can mean green: Buck offers the 635 PakLite Cape in "O.D. Green Micarta Pro," and a listing for that knife with GRN in its name prints micarta in its Handle row. The Handle row, not the name, tells the material.